Search results for "Materials Physics"

showing 10 items of 19 documents

A versatile bioreactor for dynamic suspension cell culture. Application to the culture of cancer cell spheroids.

2016

A versatile bioreactor suitable for dynamic suspension cell culture under tunable shear stress conditions has been developed and preliminarily tested culturing cancer cell spheroids. By adopting simple technological solutions and avoiding rotating components, the bioreactor exploits the laminar hydrodynamics establishing within the culture chamber enabling dynamic cell suspension in an environment favourable to mass transport, under a wide range of tunable shear stress conditions. The design phase of the device has been supported by multiphysics modelling and has provided a comprehensive analysis of the operating principles of the bioreactor. Moreover, an explanatory example is herein prese…

0301 basic medicineBiophysical SimulationsMaterials scienceMultiphysicsMaterials ScienceBiophysicslcsh:MedicineMarine and Aquatic SciencesApoptosisFluid MechanicsResearch and Analysis MethodsContinuum Mechanics03 medical and health sciencesMaterials PhysicsWater QualityShear stressBioreactorIntercellular connectionDissolved Oxygenlcsh:ScienceSuspension (vehicle)Shear StressesFlow RateMultidisciplinaryCell DeathPhysicslcsh:RSpheroidClassical MechanicsBiology and Life SciencesComputational BiologyFluid DynamicsCell BiologyCell CulturesSuspension CulturesShear (sheet metal)030104 developmental biologyCell ProcessesCell culturePhysical SciencesEarth SciencesMechanical Stresslcsh:QBiological CulturesSedimentationBiological systemResearch Article
researchProduct

Grey Matter Microstructural Integrity Alterations in Blepharospasm Are Partially Reversed by Botulinum Neurotoxin Therapy.

2016

OBJECTIVE Benign Essential Blepharospasm (BEB) and hemifacial spasm (HFS) are the most common hyperkinetic movement disorders of facial muscles. Although similar in clinical presentation different pathophysiological mechanisms are assumed. Botulinum Neurotoxin (BoNT) is a standard evidence-based treatment for both conditions. In this study we aimed to assess grey matter microstructural differences between these two groups of patients and compared them with healthy controls. In patients we furthermore tracked the longitudinal morphometric changes associated with BoNT therapy. We hypothesized microstructural differences between the groups at the time point of maximum symptoms representation a…

0301 basic medicineCentral Nervous SystemMaleMovement disordersBotulinum ToxinsBlepharospasmlcsh:MedicineToxicologyPathology and Laboratory MedicineNervous SystemDiagnostic Radiology0302 clinical medicineMaterials PhysicsMedicine and Health SciencesToxinsLongitudinal StudiesGray Matterlcsh:ScienceMicrostructureMultidisciplinaryMovement DisordersRadiology and ImagingPhysicsMotor CortexBrainNeurodegenerative DiseasesAnatomyMiddle AgedMagnetic Resonance ImagingPathophysiologyBotulinum neurotoxinFacial musclesDystoniamedicine.anatomical_structureTreatment OutcomeNeurologyPhysical SciencesFemalePrimary motor cortexmedicine.symptomAnatomyResearch ArticleAdultmedicine.medical_specialtyImaging TechniquesBlepharospasmToxic AgentsBacterial ToxinsMaterials ScienceBotulinum ToxinGrey matterResearch and Analysis Methods03 medical and health sciencesDiagnostic MedicineOphthalmologymedicineHumansHemifacial SpasmDemographyAgedbusiness.industrylcsh:RBiology and Life SciencesCorrectionmedicine.disease030104 developmental biologyCross-Sectional StudiesFacePeople and Placeslcsh:QbusinessHead030217 neurology & neurosurgeryHemifacial spasmPloS one
researchProduct

The shell of the invasive bivalve species Dreissena polymorpha: biochemical, elemental and textural Investigations.

2016

28 pages; International audience; The zebra mussel Dreissena polymorpha is a well-established invasive model organism. Although extensively used in environmental sciences, virtually nothing is known of the molecular process of its shell calcification. By describing the microstructure, geochemistry and biochemistry/proteomics of the shell, the present study aims at promoting this species as a model organism in biomineralization studies, in order to establish a bridge with ecotoxicology, while sketching evolutionary conclusions. The shell of D. polymorpha exhibits the classical crossed-lamellar/complex crossed lamellar combination found in several heterodont bivalves, in addition to an extern…

0301 basic medicinelcsh:MedicineInvasive Species010501 environmental sciencesProteomicsEcotoxicology01 natural sciencesBiochemistrychemistry.chemical_compoundDatabase and Informatics MethodsMaterials PhysicsLectinsMusselslcsh:ScienceMicrostructureGel ElectrophoresisStainingMineralsMultidisciplinarybiologyOrganic CompoundsPhysicsMonosaccharidesBiological EvolutionEuropeChemistry[ SDV.BBM.GTP ] Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN]Physical SciencesFranceSequence AnalysisResearch ArticleSilver StainingBivalvesMaterials ScienceShell (structure)CarbohydratesSequence DatabasesElectrophoretic StainingResearch and Analysis MethodsDreissenaDreissenaCoomassie Blue staining03 medical and health sciencesElectrophoretic TechniquesSpecies ColonizationAnimal Shells[SDV.BBM.GTP]Life Sciences [q-bio]/Biochemistry Molecular Biology/Genomics [q-bio.GN]Botany[SDV.BBM] Life Sciences [q-bio]/Biochemistry Molecular BiologyEcotoxicologyAnimals[SDV.BBM]Life Sciences [q-bio]/Biochemistry Molecular Biology14. Life underwaterShell calcificationMolecular Biology TechniquesSequencing Techniques[SDV.IB.BIO]Life Sciences [q-bio]/Bioengineering/BiomaterialsMolecular Biology[ SDV.BBM ] Life Sciences [q-bio]/Biochemistry Molecular Biology0105 earth and related environmental scienceslcsh:ROrganic ChemistryEcology and Environmental SciencesOrganismsChemical CompoundsBiology and Life SciencesProteinsMolluscs[ SDV.IB.BIO ] Life Sciences [q-bio]/Bioengineering/Biomaterialsbiology.organism_classificationInvertebrates030104 developmental biologyCalcium carbonateBiological DatabaseschemistrySpecimen Preparation and TreatmentZebra mussellcsh:QIntroduced SpeciesBiomineralization
researchProduct

Temperature-induced microstructural changes in shells of laboratory-grown Arctica islandica (Bivalvia).

2021

Bivalve shells are increasingly used as archives for high-resolution paleoclimate analyses. However, there is still an urgent need for quantitative temperature proxies that work without knowledge of the water chemistry–as is required for δ18O-based paleothermometry–and can better withstand diagenetic overprint. Recently, microstructural properties have been identified as a potential candidate fulfilling these requirements. So far, only few different microstructure categories (nacreous, prismatic and crossed-lamellar) of some short-lived species have been studied in detail, and in all such studies, the size and/or shape of individual biomineral units was found to increase with water temperat…

BiomineralizationAtmospheric Science010504 meteorology & atmospheric sciencesPhysiologyScanning electron microscopeArctica islandica010502 geochemistry & geophysicsBiochemistry01 natural sciencesMachine LearningMaterials PhysicsPhase (matter)Image Processing Computer-AssistedElectron MicroscopyMicrostructureClimatologyMicroscopyMultidisciplinaryAgricultural and Biological Sciences(all)biologyPhysicsQTemperatureREukaryotaSoftware EngineeringMicrostructureAdaptation PhysiologicalDiagenesisPhysical SciencesEngineering and TechnologyMedicineScanning Electron MicroscopyPaleotemperaturePorosityResearch ArticleBivalvesComputer and Information SciencesMaterials scienceBaltic SeaImaging TechniquesScienceMaterials ScienceShell (structure)MineralogyResearch and Analysis MethodsComputer SoftwareAnimal ShellsBodies of waterAnimalsPaleoclimatologyGeneralArctica islandica0105 earth and related environmental sciencesBiochemistry Genetics and Molecular Biology(all)MorphometryOrganismsPaleontologyWaterBiology and Life SciencesMolluscsbiology.organism_classificationBivalviaInvertebratesBivalviaMarine and aquatic sciencesEarth sciencesMicroscopy Electron ScanningLaboratoriesPhysiological ProcessesZoologySoftwareGenetics and Molecular Biology(all)BiomineralizationPLoS ONE
researchProduct

Fracture resistance and the mode of failure produced in metal-free crowns cemented onto zirconia abutments in dental implants.

2019

The purpose of the investigation was to analyze fracture resistance and mode of failure of zirconium oxide (zirconia) abutments placed on dental implants bearing crowns of different esthetic materials: zirconia, lithium disilicate (LDS), and nano-ceramic resin, for replacing single teeth in the anterior sector. Eighty implant-abutment-crown units were divided into four groups: Group T-MC (control): 20 metal-ceramic crowns cemented onto titanium abutments; Group Z-Z: 20 zirconia crowns on zirconia abutments; Group Z-LD: 20 lithium disilicate crowns on zirconia abutments; and Group Z-NCR: 20 nano-ceramic resin crowns on zirconia abutments. Specimens underwent a fatiguing process (dynamic load…

CeramicsTeethMedical Implantsmedicine.medical_treatmentDentistry02 engineering and technologyMaterial Fatigue0302 clinical medicineMaterials PhysicsMaterials TestingMedicine and Health SciencesCubic zirconiaDental Restoration FailureMaterialsDental CementumTitaniumProstheticsMultidisciplinaryCrownsPhysicsQRClassical Mechanics021001 nanoscience & nanotechnologyChemistryPhysical SciencesMedicineEngineering and TechnologyAnatomy0210 nano-technologyTitaniumResearch ArticleBiotechnologyChemical ElementsMaterials scienceScienceBiomaterial ImplantsMaterials ScienceAbutmentchemistry.chemical_elementBioengineeringLithiumCrown (dentistry)Anterior region03 medical and health sciencesmedicineHumansTitanium ImplantsDental ImplantsDamage Mechanicsbusiness.industryBiology and Life Sciences030206 dentistryDental PorcelainAssistive TechnologieschemistryMetal freeJawFracture (geology)Zirconium oxideMedical Devices and EquipmentZirconiumbusinessDigestive SystemHeadPloS one
researchProduct

Nanosecond voltage pulses from dendritic flux avalanches in superconducting NbN films

2013

Combined voltage and magneto-optical study of magnetic flux flow in superconducting NbN films is reported. The nanosecond-scale voltage pulses appearing during thermomagnetic avalanches have been recorded in films partially coated by a metal layer. Simultaneous magneto-optical imaging and voltage measurements allowed the pulses to be associated with individual flux branches penetrating the superconductor below the metal coating. From detailed characteristics of pulse and flux branches, the electrical field in the superconductor is found to be in the range of 5-50 kV/m, while the propagation speed of the avalanche during its final stage is found to be close to 5 km/s. peerReviewed

Condensed Matter::SuperconductivityExperimental materials physics
researchProduct

Erbija jonu augšuppārveidotā luminiscence trīskomponentu fluorīdu nanokristālus saturošā caurspīdīgā stikla keramikā

2021

Augšuppārveidotā luminiscence ir anti-Stoksa process, kurā starojums ar mazāku enerģiju tiek pārveidoti starojumā ar lielāku enerģiju. Šī procesa efektivitāti nosaka aktivatora un izmantotās matricas īpašības. Šajā pētījumā raksturota Er3+ augšuppārveidotā luminiscence oksifluorīdu stikla keramikā – kompozītmateriālā, kas sastāv no oksīdu stikla un fluorīdu nanokristāliem. Ar kausējuma dzesēšanas metodi iegūti jauni, caurspīdīgi, ar Er3+ aktivēti stikla keramikas materiāli, kas satur NaREF4 (RE=La, Gd, Y, Er, Lu) un Ba4RE3F17 (RE=Gd, Y, Yb, Lu) nanokristālus. Stiklā un stikla keramikā analizēti kristalizācijas procesi un šo materiālu spektroskopiskās īpašības. Atslēgas vārdi: erbijs, augšup…

FizikaMaterials physicsMateriālu fizika
researchProduct

Influence of competition on performance factors in under-19 soccer players at national league level.

2020

The aim of this study was to analyse and quantify the acute effects of competition on several performance factors in under-19 male soccer players. To this end, 198 national league players (17.56 ± 0.78 years) performed various tests to measure jump capacity, kicking velocity and sprint times immediately pre-match (T1), at half-time (T2) and post-match (T3). Tests included kicking the ball to measure ball velocity (KICK), sprinting for 40 meters, timing the first 30 meters (30mACCEL), the last 10 meters (10mACCEL) and the total distance (40mACCEL), and performing countermovement jumps (CMJ). For subsequent analysis, the sample was divided into 5 playing positions: goalkeepers (n = 24), defen…

MaleBall velocityAcute effectsPhysiologyVelocitySocial Sciences030204 cardiovascular system & hematologyPathology and Laboratory MedicineMaterial FatigueRunningRemote SensingMaterial fatigue0302 clinical medicineMaterials PhysicsTask Performance and AnalysisStatisticsMedicine and Health SciencesHuman PerformancePsychologyFatigueMathematicsMultidisciplinaryPhysicsQRClassical MechanicsSports ScienceSprintPhysical SciencesJumpEngineering and TechnologyMedicineResearch ArticleSportsCompetitive BehaviorAdolescentScienceAccelerationMaterials ScienceAthletic PerformanceLeagueMotion03 medical and health sciencesSigns and SymptomsCountermovementDiagnostic MedicineSoccerHumansExerciseBehaviorDamage MechanicsRadarBiological LocomotionBiology and Life Sciences030229 sport sciencesRecreationPLoS ONE
researchProduct

Comparison of Diffusion MRI Acquisition Protocols for the In Vivo Characterization of the Mouse Spinal Cord: Variability Analysis and Application to …

2016

Diffusion-weighted Magnetic Resonance Imaging (dMRI) has relevant applications in the microstructural characterization of the spinal cord, especially in neurodegenerative diseases. Animal models have a pivotal role in the study of such diseases; however, in vivo spinal dMRI of small animals entails additional challenges that require a systematical investigation of acquisition parameters. The purpose of this study is to compare three acquisition protocols and identify the scanning parameters allowing a robust estimation of the main diffusion quantities and a good sensitivity to neurodegeneration in the mouse spinal cord. For all the protocols, the signal-to-noise and contrast-to noise ratios…

MaleDTI-MRI spinal cord ALSPathologylcsh:MedicineSignal-To-Noise RatioNervous System030218 nuclear medicine & medical imagingDiagnostic RadiologyDiffusionMice0302 clinical medicineSuperoxide Dismutase-1Materials PhysicsMedicine and Health SciencesImage Processing Computer-AssistedAmyotrophic lateral sclerosisDiffusion (business)lcsh:ScienceMicrostructureMusculoskeletal SystemBrain MappingMultidisciplinarymedicine.diagnostic_testRadiology and ImagingPhysicsAnimal ModelsCondensed Matter PhysicsMagnetic Resonance Imagingmedicine.anatomical_structureDiffusion Tensor ImagingSpinal CordPhysical SciencesAnatomyResearch Articlemedicine.medical_specialtyImaging TechniquesBrain MorphometryMaterials ScienceMaterial PropertiesNeuroimagingMouse ModelsMice TransgenicResearch and Analysis Methods03 medical and health sciencesModel OrganismsDiagnostic MedicineFractional anisotropymedicineAnimalsSensitivity (control systems)AllelesProtocol (science)business.industryAmyotrophic Lateral Sclerosislcsh:RBiology and Life SciencesReproducibility of ResultsMagnetic resonance imagingmedicine.diseaseSpinal cordSpineNeuroanatomyDisease Models AnimalDiffusion Magnetic Resonance ImagingMutationAnisotropylcsh:Qbusiness030217 neurology & neurosurgeryBiomedical engineeringDiffusion MRINeurosciencePLoS ONE
researchProduct

Composing only by thought: Novel application of the P300 brain-computer interface.

2017

The P300 event-related potential is a well-known pattern in the electroencephalogram (EEG). This kind of brain signal is used for many different brain-computer interface (BCI) applications, e.g., spellers, environmental controllers, web browsers, or for painting. In recent times, BCI systems are mature enough to leave the laboratories to be used by the end-users, namely severely disabled people. Therefore, new challenges arise and the systems should be implemented and evaluated according to user-centered design (USD) guidelines. We developed and implemented a new system that utilizes the P300 pattern to compose music. Our Brain Composing system consists of three parts: the EEG acquisition d…

MaleMan-Computer InterfaceVisual Analog ScaleComputer sciencePhysiologyInterface (computing)lcsh:MedicineSocial Sciences02 engineering and technologyMusicalMaterial FatigueTask (project management)Thinking0302 clinical medicineSoftwareHuman–computer interactionMaterials PhysicsSoftware DesignSurveys and QuestionnairesTask Performance and AnalysisMedicine and Health SciencesPsychologylcsh:ScienceClinical NeurophysiologyBrain MappingMultidisciplinaryMusic psychologyPhysicsClassical MechanicsSoftware EngineeringElectroencephalographyElectrophysiologyBioassays and Physiological AnalysisBrain ElectrophysiologyResearch DesignBrain-Computer InterfacesPhysical SciencesSoftware designEngineering and TechnologyFemaleResearch ArticleAdultComputer and Information SciencesImaging Techniques0206 medical engineeringMaterials ScienceNeurophysiologyNeuroimagingResearch and Analysis MethodsComputer Software03 medical and health sciencesHumansBrain–computer interfaceBehaviorDamage MechanicsMusic Cognitionbusiness.industrySIGNAL (programming language)lcsh:RElectrophysiological TechniquesCognitive PsychologyBiology and Life SciencesPilot StudiesAcoustics020601 biomedical engineeringEvent-Related Potentials P300Human Factors EngineeringCognitive Sciencelcsh:QClinical MedicinebusinessBioacoustics030217 neurology & neurosurgeryNeurosciencePloS one
researchProduct